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Fullmetal Alchemist Volume 16: 05/09/12
Fullmetal Alchemist Volume 16 by Hiromu Arakawa takes the series in a new direction. Friends and colleagues are scattered.
Roy Mustang's squad is broken up and deployed to the four corners of the country, with Hawkeye being made Bradley's assistant. Mirroring their deployments, Ed, Al and the others split up. Ed and Al head north while others head east and west in hopes of keeping the scent off the brothers.
There's hope in frozen north of Fort Briggs in the form of a cut-throat leader and her well trained troops. There's danger beyond Briggs and the Homunculi have something planned below the surface.
This far along in the series there's no point in starting here. You're either following it from the beginning or you're not. It doesn't stand alone but it does expand the world building.